kras g12c inhibitor 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11776	KRas G12C inhibitor 1		Ras
	KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.		Ras
T77805	KRAS G12C mutant protein inhibitor A-1

T11224	Rineterkib	ERK-IN-1	ERK , Raf
	Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.		ERK , Raf
T62566	KRAS G12C inhibitor 53
	KRAS G12C inhibitor 53 (Compound 1) is a KRAS G12C inhibitor.
T11768	KRAS G12C inhibitor 14		Ras
	KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].		Ras
T79057	KRAS G12C inhibitor 58		Ras
	KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].		Ras
T72335	KRAS G12C inhibitor 32		Ras
	KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].		Ras
T72336	KRAS G12C inhibitor 45
	KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .
T79166	KRAS G12C inhibitor 60		Ras
	KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and pancreatic cancers [1].		Ras
T64085	KRAS G12C inhibitor 43
	KRAS G12C inhibitor 43 is a potent inhibitor of KRAS G12C and inhibits the migration and proliferation of H358 cells (IC50: 0.001-1 μM μM), A549 cells (IC50>1 μM) and HCC cells (IC50>1 μM).
T78651	Glecirasib	JAB-21822,KRAS G12C inhibitor 36	Ras
	Glecirasib (KRAS G12C inhibitor 36) is a potent inhibitor targeting the oncogenic KRAS G12C mutation, a key signaling molecule within the Ras protein family that is crucial for cell growth and development. This compound ...		Ras
T79799	Pan-KRAS-IN-4		Ras
	Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].		Ras
T73396	ARS-2102
	ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .
T62751	KRAS inhibitor-12
	KRAS inhibitor-12 (compound 6-1) is a potent inhibitor of KRAS G12C (IC50: 0.537 μM). KRAS inhibitor-12 exhibits p-ERK inhibition in MIA PaCA-2, A549 cells with IC50 values of 1.3, 3.7 μM respectively. KRAS inhibitor-12 ...
T79092	TH-Z827		Ras
	TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C). Additionally, it disrupts the KRAS(G12D)-CRAF interaction with an I...		Ras
T75131	RMC-6291
	RMC-6291 is an orally active and covalent inhibitor of KRAS G12C (ON) . RMC-6291 forms a tri-complex within tumor cells between KRAS G12C (ON) and cyclophilin A (CypA). Thus, RMC-6291 prevents KRAS G12C (ON) from signali...
T72971	(S)-JDQ-443	(S)-NVP-JDQ443
	(S)-JDQ-443 is an isomer of JDQ-443 . JDQ-443 is an orally active, potent, selective, and covalent KRAS G12C inhibitor. JDQ-443 shows antitumor activity [1] [2] .
T79808	KRAS G12C inhibitor 61		ERK
	KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM. This inhibitor is applicable in the research of pancreatic, colorecta...		ERK
T79800	Pan-KRAS-IN-2		Ras
	Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly...		Ras
T75119	KRASG12C IN-2
	KRASG12C IN-2 (compound 17) is an orally active inhibitor of KRAS G12C, which effectively suppresses tumor growth in mice [1].